Research Interests

The broad focus of my research is to learn how to associate changes in genotype with changes in phenotype in mammals. In particular, I study mammalian cis-regulation and the evolution of cis-regulatory elements. I am also interested in designing computational methods to assess likely functions for sets of cis-regulatory elements.

Publications

  1. McLean CY*, Reno PL*, Pollen AA*, Bassan AI, Capellini TD, Guenther C, Indjeian VB, Lim X, Menke DB, Schaar BT, Wenger AM, Bejerano G, Kingsley DM. Human-specific loss of regulatory DNA and the evolution of human-specific traits, Nature, 471(7337):216-219, 2011. * Authors contributed equally. [Abstract].
  2. McLean CY, Bristor D, Hiller M, Clarke SL, Schaar BT, Lowe CB, Wenger AM, Bejerano G. GREAT improves functional interpretation of cis-regulatory regions, Nature Biotechnology, 28(5):495-501, 2010. [Abstract] [Permanent link] [pdf] [Website].
  3. McLean C and Bejerano G. Dispensability of mammalian DNA, Genome Research, 18(11):1743-1751, 2008. [Abstract] [pdf].

Talks

  1. Cold Spring Harbor Laboratory: The Biology of Genomes, Cold Spring Harbor, NY, 13 May 2010.
  2. Georgia Tech and Oak Ridge Natl. Lab International Conference on Bioinformatics, Atlanta, GA, 13 November 2009. Plenary talk in substitution for Gill Bejerano.
  3. Biomedical Computation at Stanford Symposium, Stanford, CA, 7 November 2009. 2nd place for Best Talk award.
  4. Bio-X Fellows Symposium, Stanford, CA, 1 July 2009.

Posters

  1. Cold Spring Harbor Biology of Genomes, Cold Spring Harbor, NY, 14 May 2010.
  2. Gordon Research Conference on Human Genetics and Genomics, Biddeford, ME, 20 July 2009.
  3. Stanford Computer Forum 2009 Plenary Meeting, Stanford, CA, 15 April 2009.
  4. Cold Spring Harbor Systems Biology meeting, Cold Spring Harbor, NY, 29 March 2008.